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Second, improvements in IR and glycaemic indices are most apparent in higher-burden phenotypes, particularly in women with impaired glucose tolerance/prediabetes or related metabolic comorbidities, where changes in HOMA-IR, fasting glucose and OGTT profiles are more pronounced and may plausibly reduce periconception metabolic risk

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Conclusion Vitamin B12 injections are a powerful and effective way to correct or prevent B12 deficiency, especially in individuals with absorption issues or specific health conditions

These results should be interpreted with a qualified healthcare provider and do not predict exact medication responserather, they offer context for individual metabolic phenotypes and may support more informed treatment planning