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It was designed to investigate the efficacy and safety of 0.25mg and 0.50 mg oral tesofensine compared to placebo in 372 obese patients

Even microdosing GLP-1 receptor agonists has led to a remarkable decrease in pain, morning stiffness, and flare frequencyeven for those who didnt qualify for high-dose weight-loss prescriptions

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Both have distinct yet complementary mechanisms that, when combined, may offer synergistic benefits

2- NSAIDs: show no statistically significant pain relief compared to placebo in osteoarthritis patients