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A further interesting anti cancer effect of metformin was the ability to reduce the TNF--induced CXCL8 secretion by thyroid cells in vitro

It has been consistently demonstrated in multiple datasets that ACE2 mRNA is expressed in both human thyroid tissues and primary cultured cells, suggesting that the thyroid could be vulnerable to direct viral infection and its cytopathic effects (164)

Nelson DB, Lapid DJ, Mitchell KG, Correa AM, Hofstetter WL, Mehran RJ, Rice DC, Sepesi B, Walsh GL, Vaporciyan AA, Swisher SG , Roth JA, Antonoff MB

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