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This is also why a secretagogue approach is framed as "axis-friendly": because endogenous somatostatin is still in the loop, negative feedback is preserved, which in principle restrains the supraphysiologic IGF-1 spikes seen with exogenous GH

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GLP-1 receptor agonists are peptide drugs cleared through proteolytic cleavage essentially broken down by the same enzymatic processes that digest dietary protein

Empirical valence bond simulations of the hydride transfer step in the monoamine oxidase B catalyzed metabolism of dopamine

Doxorubicin, an effective anticancer drug, is associated with dose-dependent cardiotoxicity, primarily manifesting as cardiomyopathy

1983;127(2):20515 Lahoti TS, Patel D, Thekkemadom V, Beckett R, Ray SD