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In addition, castration also increased the expression of ROS-production related genes such as Nox1 and GP91PHOX (the catalytic subunit of Nox2) and decreased the levels of antioxidant enzymes such as superoxide dismutase 2 (SOD2), glutathione peroxidase 1 (GPX1), thioredoxin, and peroxiredoxin 5 in the prostate alveolar epithelium of rats (125)

The clinical success of dental implants primarily depend on the direct structural and functional connection between the living bone and the implant surface, which is referred to as osseointegration (Wang et al., 2021a