GS143 - IkappaB Ubiquitination Inhibitor. CAS# 916232-21-8 187 Specifically

Specifically

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is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) which plays an important role in many pathways

TAE684 inhibits STAT3 and STAT5 phosphorylation in a dose-dependent manner in both Ba/F3 NPM-ALK and Karpas-299 cells

GS143 - IkappaB Ubiquitination Inhibitor. CAS# 916232-21-8 187 SpecificallyGS143, CAS No. 916232 21 8, is selective TrCP1 ligase inhibitor, inhibits IB ubiquitination with IC50 ~5. 2 M without affecting proteasome activity. It blocks LPS induced expression of inflammatory cytokines in human myelomonocytic cells. It suppresses antigen induced NFB expression, inflammation and mucus production in airways of OVA sensitized mice. Product information CAS Number: 916232 21 8 Molecular Weight: 466. 46 Formula: C28H19FN2O4 Chemical