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6 The SURMOUNT-1 Trial found weight loss at all three doses of tirzepatide (5, 10, 15mg) with the most significant weight loss in the 15mg group with a reported 20.9% mean weight loss as compared to 3.1% for placebo over a 72 week trial

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[DOI] [PMC free article] [PubMed] [Google Scholar] 41.Dalle-Donne I., Rossi R., Colombo G., Giustarini D., Milzani A

These medications have undergone rigorous testing and review and the FDA has determined they are safe for long-term use

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We further examined whether acute tirzepatide, a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist recently approved by the FDA for obesity, and retatrutide, an investigational triple agonist targeting GIP, GLP-1, and glucagon receptors currently in Phase 3 trials would recapitulate or enhance these effects