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Deoxypyrimidine monophosphate bypass therapy for thymidine kinase 2 deficiency

This challenge requires massive research and development

In addition to an unstimulated sample quantifying basal ROS formation, a stimulation with the protein kinase C activation agent 12-O-tetradecanoylphorbol-13-acetate (TPA) was used to induce a respiratory burst by NADPH-oxidase activity

Azzari C, la Marca G, Resti M

The plasma alanine aminotransferase (ALT) activity was measured using the Alanine Aminotransferase Activity Assay Kit MAK052 (Sigma-Aldrich) according to the manufacturers instructions and was reported as unit per liter of plasma (U/L), where 1 mU is defined as the amount of ALT generating 1 nmol of pyruvate per minute at 37 C

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