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Overall, the use of GLP-1 RAs was not associated with a higher incidence of suicide or suicide attempts in new-user active comparator cohort analyses or in self-controlled case series analyses

and Garvey WT, Frias JP, Jastreboff AM, le Roux CW, Sattar N, Aizenberg D, Mao H, Zhang S, Ahmad NN, Bunck MC, Benabbad I, Zhang XM

Rapid weight loss can mean losing not just fat, but also muscle mass

To support individuals using GLP-1 medications as well as those pursuing weight management without them, brands can focus on formulating products that deliver satiety, nutrition and convenience

For example, Vitals Apple Health integration has helped users track their meal and nutrition data

Combined with our trafficking and insulin release results, these data show a canonical role for -arrestin recruitment in promoting GLP-1R endocytosis and desensitization