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This geographical bias limiting the global generalizability of the findings, so this highlights the need for similar studies in other regions, especially in countries with rising pollution levels and limited reproductive health data, such as in South Asia, the Middle East, and Africa

269 Another study suggested that PS1 mutations may lead to the opening of another calcium ion channel, two pore segment channel 2 (TPCN2), whose markedly enhanced activity greatly promotes lysosomal calcium efflux and lysosomal alkalinization

This is because GLP-1 agonists can help counteract the physiological causes of weight regain, which can help reduce yo-yo weight cycling over time, Mitri adds