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Specifically, Pickart and Margolina published in Biomolecules summarizing over 150 published studies on GHK-Cus gene regulatory effects, establishing it as the most comprehensively studied copper peptide for extracellular matrix research

Further, proliferation and progression of tumor are controlled by the subsequently reprogrammed TME such as redox potential alteration [27], nutrient and oxygen uptake (hypoxia conditions) changes [28], and blood flow alteration [29] in the due time course

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