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It is well-established in clinical studies in humans that beetroot supplementation can improve blood flow dynamics

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Gao et al., 2010

P., Grabner, M., Punekar, R

Agonist-internalised receptors which do not follow a recycling pathway can be sorted towards lysosomal degradation, and in keeping with this, we found increased colocalisation of SNAP-GLP-1R with a fluorescent lysosomal marker after prolonged treatment with lixisenatide compared to exendin-4 (Figure 4F)