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Signs you should slow down the titration Extend your stay at the current dose by 2-4 additional weeks if you experience any of the following at the end of a standard 4-week period: Nausea persisting beyond the first 7 days after the last dose increase Vomiting more than twice per week Diarrhea lasting more than 10 days at the current dose Significant fatigue or weakness that does not improve with adequate nutrition and rest Weight loss exceeding 1.5% per week (too-rapid loss increases gallstone risk and muscle loss) Slowing the titration is not failure

The caveat is that dermatologists should aim for a PDT clearance that approaches the efficacy of 5-fluorouracil (5-FU)

But lifestyle still matters

Note: If you experience severe abdominal pain, persistent vomiting, or signs of an allergic reaction during a transition, contact your healthcare provider immediately