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Specifically, changing the Val229 residue to alanine, selected in this study for further investigation, was predicted to trigger a change in the cavity and a buried exposure switch at the inactive receptor, thereby potentially modifying the interactions between itself and other pocket residues with cholesterol

Prioritizing nutrient density Because GLP-1 therapy leads to eating smaller portions, every calorie consumed must provide high nutritional value

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Chen W, Qin H, Zhou Z, Chen Y, Xu X, Chen Y, et al