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Tirzepatide (Zepbound): Its Effects on Sleep Apnea in the Surmount-OSA Phase 3 Trial Jun 8, 2025 6 min read Key Takeaways Tirzepatide significantly reduced obstructive sleep apnea (OSA) severity in the Surmount-OSA clinical trial Tirzepatide is now FDA-approved to treat OSA in people with obesity Its an add-on therapy, not a replacement for CPAP Patients also gained health benefits beyond sleep A personalized approach to treatment is essential Patients should discuss with their healthcare provider which treatment or combination of treatments is best for them For people with sleep apnea and obesity, recent clinical research suggests that tirzepatide, sold under the brand names Zepbound and Mounjaro, may offer more benefit than weight reduction alone