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doi: 10.1074/jbc.M110.217901

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Pancreatic islet cells of ND-fed mice were regularly distributed and of uniform size, while in HF diabetic controls, the pancreatic islet cell size was inconsistent, with hyperplasia around the pancreatic duct, and pancreatic duct expansion

And with more than half of the global population (51% or over 4 billion people) predicted to be either overweight or living with obesity by 2035, investment in obesity drugs is forecast to rise by a compound annual growth rate of 35%38% between 2023 and 2027.9,10 While some GLP-1 treatments currently in the pipeline are set to reach the market in oral tablet form, autoinjectors and pen injectors currently at the forefront of GLP-1 delivery will continue to deliver multiple patient benefits across this significantly expanded market segment

Endocrinologists primarily prescribe FDA-approved brand-name GLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound

Obesity, particularly in those with android body fat distribution, are at increased risk of NAFLD and disease progression and individuals with complications such as hypertension, knee osteoarthritis, or sleep apnea should also be screened for advanced liver disease