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Gastrointestinal Effects GLP-1 medications have significant effects on the digestive system: They slow stomach emptying, increasing feelings of fullness They reduce gastric acid production They may help with inflammatory bowel diseases They enhance gut barrier protection They have anti-inflammatory effects in the digestive tract While these effects help with weight loss and blood sugar control, they can also cause side effects like nausea, vomiting, and diarrhea

These finally cause inflammation, cellular death, and fibrosis [5]

p -values below 0.05 ( ), 0.01 (#), and 0.001 () were considered as significant

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase