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In clinical studies, many participants lost between 15% and 20% after 72 weeks of treatment alongside healthy eating and regular activity

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Pharmacol Reports 69:386392

Patients with leptin resistance tend to experience at least 2 of the following symptoms: Inability to lose weight despite eating a calorie-restricted diet and exercising regularly Constant weight gain is usually accompanied by a ravenous appetite Constant food cravings, even after eating a large meal Constant fatigue, low energy, or feeling sluggish Cold body temperature(defined as less than 98.0 degrees F) Low resting heart rate(defined as 50-60 first thing in the morning assuming that you are both overweight and not aerobically conditioned) Worsening symptoms of hypothyroidism (Hypothyroidism frequently accompanies leptin resistance) These are what I call the warning signs of Leptin resistance

Additionally, a person with a BMI of 30 kg/m2 or greater can find treatment through Semaglutide GLP-1 without weight-related conditions

2021 Nov 10;12:786732